Phosphorylation of C/EBPα Inhibits Granulopoiesis

Phosphorylation of C/EBP Inhibits Granulopoiesis

Computer simulation of granulopoiesis: normal and impaired granulopoiesis.

A computer model simulating granuuse were simulated, resulted in states lopoiesis has been constructed on the resembling cyclical and severe nonbasis of two feedback loops, one concyclical neutropenia, respectively. The trolling the rate of production of granuresults provide evidence that a number locytes at the stem cell level, the other of the periodic features shown by normal controlling the...

Elevation of cAMP Levels Inhibits Doxorubicin-Induced Apoptosis in Pre- B ALL NALM- 6 Cells Through Induction of BAD Phosphorylation and Inhibition of P53 Accumulation

Recognition of the molecular mechanisms of cAMP action against DNA damage-induced apoptosis can be useful to improve the efficacy of DNA damaging therapeutic agents. Considering the critical role of bcl-2-associated death promoter (BAD) and p53 proteins in DNA damage -induced apoptosis, the aim of this study was to assess the effect of cAMP-elevating agents on these proteins in doxorubicin-trea...

Prolonged Induction Activates Cebpα Independent Adipogenesis in NIH/3T3 Cells

BACKGROUND 3T3-L1 cells are widely used to study adipogenesis and insulin response. Their adipogenic potential decreases with time in the culture. Expressing exogenous genes in 3T3-L1 cells can be challenging. This work tries to establish and characterize an alternative model of cultured adipocytes that is easier to work with than the 3T3-L1 cells. METHODOLOGY/PRINCIPAL FINDINGS INDUCED CELLS...

Alterations of granulopoiesis following chemotherapy.

Clonal proliferation of marrow granulocytic progenitor cells (GPC) in vitro and the daily urinary output of granulocytic colony-stimulating factor (CSF) were determined in two patients with acute myeloid leukemia (AML) in remission and one patient with malignant lymphoma receiving monthly pulses of chemotherapy with cytosine arabinoside and 6-thioguanine. During and immediately following therap...